Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells.
When human cord blood-derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment.In particular, the cells pass Tomato through a transitory phase known as "multilineage-primed" state.These cells are characterized by a mixed gene expression profile