GLOBAL GENOME DECOMPACTION LEADS TO STOCHASTIC ACTIVATION OF GENE EXPRESSION AS A FIRST STEP TOWARD FATE COMMITMENT IN HUMAN HEMATOPOIETIC CELLS.

Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells.

When human cord blood-derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment.In particular, the cells pass Tomato through a transitory phase known as "multilineage-primed" state.These cells are characterized by a mixed gene expression profile

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